Penetration of sulbactam-ampicillin and clavulanic acid-amoxicillin into the pelvic peritoneum
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Penetration of sulbactam-ampicillin and clavulanic acid-amoxicillin into the pelvic peritoneum.
Sixteen patients were given single intravenous injections of ampicillin (0.5 g) with sulbactam (0.5 g), and 15 patients were given amoxicillin (1 g) with clavulanic acid (0.2 g) before elective laparoscopy. At 2 h after dosing, the concentrations of the four compounds in serum and in the peritoneal fluid from the Pouch of Douglas and the ratio of each combination reached levels shown to be effe...
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A total of 97 anaerobic bacteria were tested for susceptibility to ampicillin, ampicillin-sulbactam, and amoxicillin-clavulanic acid by broth microdilution and disk elution methods, the results of which were compared with those of the reference agar dilution method. With the broth microdilution method, approximately 95% of MICs were within 1 dilution of those of the reference agar method, with ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1985
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.28.1.165